Symptom 3: Elevated Double-Stranded DNA (dsDNA) Antibodies
Within our body, there’s a vast network of antibodies, each with a specific role in identifying and neutralizing potential threats like viruses or bacteria. Among these, double-stranded DNA (dsDNA) antibodies are unique. Instead of attacking foreign invaders, they target the body’s genetic material found in the nucleus of cells. In most scenarios, the presence of elevated dsDNA antibodies points towards an autoimmune response, where the body mistakenly identifies its components as threats. For ALPS patients, this auto-reactivity can be particularly concerning.
When dsDNA antibodies are heightened, they aren’t just passively floating around. They’re actively targeting and attacking the body’s own tissues, which can result in inflammation and damage. While dsDNA antibodies can be found in various autoimmune conditions, their presence in ALPS is an indicator of the immune system’s hyper-reactivity. The damage can range from mild to severe and can affect various organs, often posing diagnostic challenges for clinicians.
Though the internal war rages silently, its repercussions can be quite evident. ALPS patients might experience fatigue, joint pain, skin rashes, or even kidney complications. Each of these manifestations is a sign of the body’s internal struggle, where it’s essentially battling itself. The skin might become more sensitive to sunlight, leading to rashes or discoloration. In extreme cases, if the kidneys are involved, it could result in nephritis, an inflammation of the kidneys that could compromise their function.(3)
