Cause 10. Environmental Factors and the Development of Amyloidosis: The Impact of Lifestyle and External Influences
The causes of amyloidosis extend beyond our genetics and internal body processes. Environmental factors can play a considerable role in the development of the disease, shedding light on the interplay between our lifestyles, external influences, and health outcomes.
Diet and nutrition, for instance, can potentially impact the risk of amyloidosis. Diets high in saturated fats and processed foods, coupled with low physical activity, can contribute to obesity and type 2 diabetes – conditions associated with an increased risk of developing a form of amyloidosis due to the overproduction of the hormone amylin.
Tobacco and alcohol use can also contribute to amyloidosis risk. Smoking can cause chronic inflammation – a state that can lead to the overproduction of serum amyloid A (SAA) protein, which can form amyloid fibrils and lead to secondary amyloidosis. Chronic alcohol abuse, on the other hand, can result in liver damage and cirrhosis, conditions associated with an increased risk of amyloidosis.
Exposure to certain toxins or infectious agents in the environment might also play a role in the development of amyloidosis, although more research is needed in this area to establish clear links.(10)
