Cause 3. Chronic Inflammation and Secondary Amyloidosis: The Long-term Impact of Persistent Inflammation
In the complex world of disease causation, chronic inflammation stands as a notable factor contributing to the development of secondary amyloidosis, also known as AA amyloidosis. This condition is characterized by the accumulation of amyloid protein in various organs, instigated by prolonged or repeated bouts of inflammation.
Inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and familial Mediterranean fever are known to prompt the overproduction of serum amyloid A protein (SAA). This protein, typically harmless in its regular state, becomes a culprit when persistently high levels lead to its fragmenting into amyloid A proteins. These fragments are unstable and prone to forming the sticky amyloid fibrils that deposit in organs and tissues, leading to secondary amyloidosis.
Notably, this form of amyloidosis is less common in developed countries, thanks in part to the availability of effective anti-inflammatory treatments. However, it remains a challenge in parts of the world where chronic infectious diseases are more prevalent, and access to treatment may be limited. Understanding the connection between chronic inflammation and secondary amyloidosis underscores the importance of effectively managing inflammatory and infectious diseases. (3)
