10. Hormone Replacement Therapy (HRT): The Controversial Link
Hormone replacement therapy (HRT) is a treatment used to relieve symptoms of menopause, such as hot flashes and vaginal dryness. While HRT can be beneficial for some women, it has also been associated with an increased risk of certain cancers, including liver cancer.
Some studies have suggested that the use of HRT, particularly estrogen-only formulations, may increase the risk of liver cancer. The exact mechanism by which HRT may contribute to liver cancer development is not well understood, but it may involve the stimulation of liver cell growth by estrogen or the generation of DNA-damaging reactive oxygen species.
However, the evidence on the association between HRT and liver cancer risk is not entirely consistent, and more research is needed to clarify the relationship. In the meantime, healthcare providers should carefully weigh the potential benefits and risks of HRT for each individual patient and consider alternative treatments for menopausal symptoms when appropriate.
For women who do choose to use HRT, it is important to use the lowest effective dose and the shortest duration of therapy necessary to manage menopausal symptoms. Regular monitoring of liver health and liver cancer risk is also essential for women using HRT, as early detection and intervention can help prevent the progression to liver cancer. (10)
