Symptom 4: Muscle Weakness
Muscle strength is fundamental to daily activities, from lifting objects to simply standing up from a seated position. With Cushing’s disease, there’s a distinct and noticeable reduction in muscle strength. This isn’t about not feeling strong enough to lift heavy weights but more about a noticeable difference in performing daily tasks.
The muscle weakness often manifests in the legs. Individuals might find it challenging to climb stairs, stand from a low seat, or even maintain prolonged standing. This isn’t about laziness or lack of willpower; it’s a genuine decline in muscle strength, which can be both frustrating and alarming for those experiencing it.
But why does this happen? The surge in cortisol levels adversely affects muscle protein synthesis. This hampers muscle growth and repair, leading to atrophy or muscle wasting over time. It’s like the body’s very foundations are getting eroded, leading to an increasing instability and weakness.
Rather than accepting this as a normal part of aging or an inevitable decline, recognizing it as a potential symptom of Cushing’s disease is paramount. With appropriate intervention and treatment, this muscle weakness can be managed, and in many cases, reversed. (4)
