7. Age Dynamics: MCC’s Preference for the Elderly
A significant pattern has emerged over the years, linking MCC predominantly with older age groups. The majority of MCC cases are diagnosed in individuals over the age of 50. The factors behind this age bias open avenues for discussions on cell senescence, immunity decline, and cumulative sun exposure.
With age, the skin undergoes multiple changes. Cells might not repair DNA damage as efficiently, making the elderly more vulnerable to malignancies. The immune system’s vigor also wanes with time, potentially leading to decreased surveillance against rogue cells. These combined factors can create a fertile ground for MCC initiation and progression.
There’s also the consideration of accumulated UV damage over the years. An older individual has had more sun exposures, increasing the odds of UV-induced mutations. It’s a testament to the long-term impact our environment can exert on health, even if it manifests decades later. (7)
