2. Motor Weakness: Not Just a Passing Fatigue
Another major red flag for PML is motor weakness. We’re not speaking of occasional tiredness or the kind of fatigue one might feel after a strenuous workout.
PML-induced motor weakness is a beast of a different kind. It starts subtle, perhaps with a minor difficulty in gripping objects or slight challenges in walking.
However, as the white matter in the brain continues to degrade, these issues escalate. Limbs might refuse to cooperate, leading to tremors, spasms, or even complete immobility in extreme cases. This is deeply concerning, especially considering the rapid progression in some patients.
Beyond just the physical manifestations, motor weakness brings with it a range of psychological challenges. The sudden inability to perform basic tasks can be a significant blow to one’s self-esteem and mental well-being. Additionally, the physical limitations imposed by this symptom can lead to secondary health complications, further complicating the overall prognosis for the patient. (2)
