2. Swelling of the Ankles and Legs: The Telltale Sign of Fluid Retention
Another common symptom of amyloidosis in women is swelling of the ankles and legs, often caused by fluid retention. This can occur when amyloid deposits impair the function of the kidneys or heart, leading to an imbalance in the body’s fluid levels. As a result, fluid may accumulate in the lower extremities, causing noticeable swelling and discomfort.
In the case of kidney involvement, amyloidosis can lead to a condition called nephrotic syndrome. This occurs when the kidneys’ filtering units, known as glomeruli, are damaged, allowing large amounts of protein to leak into the urine. Consequently, the body’s fluid balance is disrupted, causing swelling in the legs and ankles.
Swelling of the lower extremities can also be a sign of heart-related amyloidosis, known as cardiac amyloidosis. When amyloid proteins accumulate in the heart tissue, they can interfere with the heart’s ability to pump blood effectively, leading to fluid buildup in the body and, subsequently, swelling in the legs and ankles. Cardiac amyloidosis may also cause other symptoms, such as shortness of breath and chest pain, which can further indicate the need for medical evaluation.
If you notice unexplained swelling in your ankles and legs, it’s essential to consult with a healthcare professional. While there are many possible causes for fluid retention, ruling out amyloidosis is crucial for timely diagnosis and treatment. (2)
