10 Symptoms of Monoclonal Gammopathy of Undetermined Significance (MGUS) You Need to Know

Symptom 9: Weight Loss

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Weight Loss
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Losing weight can be a cause for celebration for many. However, when weight loss is unintended and inexplicable, it can be a cause for concern. If the numbers on the scale keep dwindling without any significant changes to diet or exercise, it’s time to delve deeper.

This isn’t about shedding a pound or two. It’s a noticeable decrease in weight over a short period, say, losing more than 5% of one’s weight within six months without trying. Such a drop can be alarming and might be accompanied by a loss of appetite and changes in metabolism.

The link between MGUS and weight loss can be attributed to the body’s response to the abnormal proteins. These proteins can affect metabolic processes, leading to unintentional weight loss. Additionally, other associated symptoms of MGUS, such as frequent infections or bone pain, can indirectly influence weight by impacting appetite and overall health.

Beyond the physical implications of weight loss, such as reduced energy and increased vulnerability to illnesses, there’s an emotional dimension. Sudden weight loss can affect self-image and confidence, and the underlying uncertainty can be distressing.(9)

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