10 Telltale Signs of Multiple Myeloma: An In-Depth Examination

Sign 2: Fatigue

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Fatigue
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Fatigue associated with multiple myeloma is a beast of a different kind. It’s not the usual tiredness that disappears after a good night’s rest. It’s relentless, draining every ounce of energy, making even mundane tasks feel mountainous. For many, it’s the kind of weariness that weighs heavy, mentally and physically.

At its core, this fatigue stems from anemia—a decline in red blood cells. Red blood cells are responsible for carrying oxygen throughout the body. When their count drops, the body struggles to function efficiently, leading to exhaustion. Moreover, the body’s constant battle against myeloma cells further depletes energy reserves.

Another contributor is the body’s metabolic shift. The disease can interfere with nutrient absorption and energy production. As a result, despite consuming enough food, patients often feel starved of vitality. The constant state of energy deficiency impacts mood, concentration, and overall quality of life.

Sleep disturbances, another common complaint among myeloma patients, further compound the fatigue. Whether it’s due to pain, anxiety about the diagnosis, or side effects of treatment, interrupted sleep cycles ensure that fatigue remains a constant companion. (2)

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