Sign 5: Kidney Problems
The kidneys, two bean-shaped organs located at the back of the abdomen, have a monumental task—filtering out waste products and excess substances, including water, from the blood. Acting as the body’s natural detox system, they ensure our system isn’t clogged with unwanted materials. The importance of these organs cannot be overstated, and when they falter, the repercussions can be widespread and severe.
Multiple myeloma has a sinister way of interfering with the kidneys’ regular function. One of the prime culprits is the abnormal proteins produced by myeloma cells. Unlike regular proteins, these are bulkier and not easily processed by the kidneys. Imagine trying to force a square peg through a round hole. The continual strain of trying to filter these abnormal proteins can not only cause obstructions but can also result in direct injury to the kidney tissues. Over prolonged periods, this can lead to reduced efficiency in filtration, or worse, complete kidney failure.
Another pressing issue stems from the elevated levels of calcium in the bloodstream, a consequence of bone breakdown due to the disease. Bones, when compromised by myeloma, release excess calcium. The kidneys, in their attempt to maintain balance, work overtime to excrete this surplus. However, they aren’t equipped to handle such persistent overloads. This added strain further jeopardizes their function, and the accumulation of calcium can lead to painful kidney stones or other complications.
While treatment for multiple myeloma is essential, certain medications come with a caveat—they can be nephrotoxic. This means that while they’re combating the disease, they might simultaneously be stressing the kidneys. It’s a delicate balance for medical professionals: ensuring the disease is kept at bay while not compromising kidney health. (5)
