Symptom 3: Skin Flushing
Skin flushing, particularly on the face and neck, is a distinctive symptom of PanNETs. This isn’t your typical blush from embarrassment or a flush post a spicy meal. It’s a pronounced redness, often accompanied by a sensation of warmth or burning. The skin might appear patchy, with distinct areas of red juxtaposed against normal skin tone.
This flushing arises due to hormone imbalances often tied with PanNETs. The tumor can sometimes lead to an overproduction of certain hormones, which in turn cause the blood vessels to dilate. This dilation manifests as a flush, especially on the skin’s surface. The episodes can be random, sometimes triggered by stress, food, or even without any discernible cause. They can last from a few minutes to hours, and in severe cases, might be accompanied by a drop in blood pressure or an elevated heart rate.
Apart from the visible flush, these episodes can be quite uncomfortable. Individuals might experience a tightness or tingling sensation, particularly on their face. There might also be associated symptoms, like diarrhea or shortness of breath, tying back to the hormone imbalance. Chronic flushing can also lead to skin changes over time. Prolonged dilation can cause the skin, especially on the face, to appear more textured or coarse. (3)
