Symptom 6: Gastric Ulcers
Gastric ulcers, or ulcers in the stomach lining, can be excruciating. These sores arise due to an imbalance between the stomach’s acid production and its protective mechanisms. PanNETs can play a role here, leading to an overproduction of stomach acid. This acid, in turn, can erode the stomach’s protective lining, leading to ulcers.
Symptoms often revolve around stomach discomfort. There might be a persistent burning sensation, especially on an empty stomach or late at night. Eating might provide temporary relief, but the pain usually returns. Some might also experience nausea, bloating, or even vomiting, especially if the ulcer is bleeding.
The connection between PanNETs and ulcers stems from a specific type of tumor known as a gastrinoma. These tumors produce an excess of the hormone gastrin, which stimulates acid production. Over time, as acid levels rise, the stomach’s lining becomes more susceptible to damage, culminating in ulcers. These ulcers might not just be limited to the stomach; they can also appear in the duodenum, the initial part of the small intestine.
Diagnosing ulcers usually involves an endoscopy, where a camera examines the stomach’s interior. However, if PanNETs are suspected, other tests, like measuring gastrin levels, might also be conducted. Treatment often involves acid-lowering medications, but addressing the underlying tumor is crucial for long-term relief.(6)
