Symptom 7: Jaundice
Jaundice, a distinct yellowing of the skin and eyes, is a potent signal of liver or bile duct disturbances. In the context of PanNETs, this symptom arises due to the tumor obstructing the bile ducts. These ducts, essential for carrying bile from the liver to the intestine, can get compressed as the tumor grows, leading to bile buildup in the bloodstream.
The initial signs might be subtle. There might be a mild yellowing of the eyes, especially noticeable in natural light. Over time, as bile levels rise, the skin might also adopt a yellowish hue. Apart from the visible signs, jaundice can also cause itching, as bile salts accumulate in the skin. Some might also notice a darkening of their urine or a pale, clay-like color to their stools.
The implications of jaundice extend beyond mere color changes. Bile, essential for digesting fats, might not reach the intestine, leading to malabsorption. This can result in greasy, foul-smelling stools and nutritional deficiencies. Additionally, the underlying cause of the obstruction, in this case, the PanNET, might continue to grow, leading to other complications.(7)
