Symptom 15. Liver Enlargement: A Critical Early Sign of Amyloidosis Affecting the Liver
The liver, a vital organ responsible for detoxification, metabolism, and many other essential functions, can be affected by amyloidosis. When amyloid proteins accumulate in the liver, it can lead to liver enlargement, also known as hepatomegaly, which serves as a critical early sign of liver involvement in amyloidosis.
Amyloidosis-related liver enlargement occurs as a result of the amyloid deposits infiltrating the liver tissues, causing them to become enlarged and distended. This enlargement can be detected during a physical examination by a healthcare professional.
It’s important to note that liver enlargement can occur due to various other conditions as well. However, when combined with other symptoms suggestive of amyloidosis, such as fatigue, weight loss, or other organ involvement, it becomes important to consider the possibility of amyloidosis affecting the liver.
Liver enlargement in amyloidosis can be associated with other liver-related symptoms, including abdominal discomfort or pain in the upper right side of the abdomen, jaundice (yellowing of the skin and eyes), and abnormalities in liver function tests. (15)
