Fact 7: Genetic Links
It’s not mere chance that some families report multiple cases of Crohn’s disease. Delving into genetics reveals that certain genes can make individuals more susceptible. A significant breakthrough was the discovery of the NOD2 gene, which is more prevalent in individuals with Crohn’s than in those without.
While genetics can predispose someone to Crohn’s, it’s not the only factor. Many individuals carrying these genes never develop the disease. Thus, it’s believed that a combination of genetic, environmental, and potentially other factors coalesce to trigger the disease’s onset.
Research suggests that those with a family member with Crohn’s are more likely to develop it. Approximately 20% of people with Crohn’s have a close relative with some form of IBD, bolstering the genetic connection theory.
While the NOD2 gene remains a significant focus, other genes are also under scrutiny. Understanding these genetic markers better might pave the way for more personalized treatment options in the future.
As we deepen our understanding of the genetic underpinnings of Crohn’s, there’s potential for predictive testing. By identifying those at higher risk early on, preventive measures or early interventions could become a reality. (7)
