15 Essential Facts about Diabetes and Dementia You Should Know

Fact 11: The Link Between Insulin Resistance and Cognitive Decline

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The Link Between Insulin Resistance and Cognitive Decline
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Insulin resistance, a key feature of type 2 diabetes, is increasingly being linked to cognitive decline. Insulin isn’t just involved in regulating blood sugar levels; it also plays a crucial role in brain function, including memory and learning.

In the context of insulin resistance, the brain’s ability to utilize insulin effectively is compromised, potentially leading to a deficiency in energy supply to brain cells. Over time, this could contribute to cognitive decline and increase the risk of dementia.

Interestingly, some research studies suggest that insulin resistance in the brain might occur independently of peripheral insulin resistance, as seen in type 2 diabetes. This suggests that therapies targeting brain insulin resistance could potentially benefit cognitive function, even in individuals without diabetes.(11)

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