Fact 5: Diagnosis and Detection
Ironically, for many, MGUS is a silent companion. Most individuals aren’t even aware they have it because clear symptoms often don’t manifest. Thus, it’s commonly discovered during routine blood tests for other conditions.
The Serum Protein Electrophoresis (SPEP) test is a key player in diagnosing MGUS. This test dissects the different proteins in the blood, and a spike in M proteins usually rings alarm bells. For further clarity, doctors might also order the Urine Protein Electrophoresis (UPEP) test.
In some cases, to assess bone health or search for other abnormalities, imaging tests like X-rays, MRI, or CT scans might be recommended. These offer a deeper dive into the body, providing a clearer picture of any anomalies linked to MGUS.
Bone marrow tests, though less common, can also be pivotal. By extracting a small sample of bone marrow, doctors can get a detailed view of plasma cells, assessing if they’re abnormal or higher in number than they should be. (5)
