Fact 3: Bone Lesions and Damage
Multiple Myeloma has a sinister tendency to attack bones. Over time, patients may develop holes or ‘lesions’ in their bones, particularly in the spine, skull, pelvis, and ribs. These lesions aren’t just markers of the disease; they are indicators of bone weakness and vulnerability.
The production of osteoclasts, cells responsible for bone resorption, increases, while the production of osteoblasts, cells responsible for bone formation, decreases. This imbalance leads to bones becoming frail and susceptible to fractures even from minor injuries.
Calcium released from the deteriorating bones enters the bloodstream. While calcium is essential for various bodily functions, an excess, known as hypercalcemia, can adversely affect the kidneys and other organs, leading to complications like constipation, confusion, and fatigue.
Additionally, multiple myeloma patients often grapple with bone pain. This pain arises from the lesions and the general weakening of the bone structure. Simple tasks such as lifting objects or even coughing might lead to fractures in advanced stages. (3)
