Fact 12: Genetics and Its Role in Pyloric Stenosis
It’s long been established that genetics play a crucial role in many health conditions, and pyloric stenosis is no exception. Infants with a family history of the disease are more prone to developing it. If a parent had pyloric stenosis as an infant, there’s an increased likelihood their offspring might experience the same.
There’s an intriguing connection between gender and pyloric stenosis. Boys are diagnosed with this condition more frequently than girls. When examining family histories, the male offspring of women who had pyloric stenosis appear to be at the highest risk. This suggests a possible genetic transmission pattern that’s linked with the X chromosome.
Studies involving twins have provided insights into the genetic predispositions of pyloric stenosis. Identical twins, who share 100% of their genes, are more likely to both exhibit symptoms if one of them has the condition, compared to fraternal twins who share only 50% of their genes. This is a compelling indication of a genetic link.
Recent advancements in genetic research have pinpointed specific gene mutations associated with pyloric stenosis. Although having these mutations doesn’t guarantee the development of the condition, their presence does elevate the risk. Genetic testing and counseling can offer insights for families with a history of the condition.(12)
