Fact 11: The Role of Genetics
There’s no denying that our genes play an instrumental role in our overall health. When exploring the realm of stomach cancer, genetics stands out as a significant contributor. Dive into the intricate dance of DNA, and one can find patterns linking genetics to susceptibility to this malignancy.
Certain genetic mutations are known to increase the risk of gastric cancer. Familial cases, where multiple members within a family are diagnosed with stomach cancer, provide a window into this genetic influence. Hereditary Diffuse Gastric Cancer (HDGC) is a prime example, where a mutation in the CDH1 gene drastically elevates the risk.
But, it’s crucial to understand that having a genetic predisposition doesn’t equate to an inevitable diagnosis. Genes might load the gun, but environmental factors often pull the trigger. Lifestyle, diet, and exposure to certain infections or carcinogens can act synergistically with genetic factors, propelling one towards disease onset.
Interestingly, advancements in genetic testing have provided a proactive approach to tackle this risk. Those with a strong family history can undergo testing to discern their susceptibility. If found at risk, preventative measures, including increased surveillance or even prophylactic surgeries, can be discussed. (11)
