15 Important Facts About Chronic Lymphocytic Leukemia (CLL, B-cell Chronic Lymphocytic Leukemia)

Fact 7: Potential Complications

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Potential Complications
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CLL doesn’t operate in isolation. Its presence often sets off a chain reaction, leading to a range of complications. Recognizing these potential pitfalls is essential to mitigate their impact and improve the patient’s quality of life.

With CLL compromising the immune system, infections become a recurring issue. Something as benign as a common cold can take a severe turn, leading to hospitalizations. Regular vaccinations, prompt treatment of minor infections, and prophylactic antibiotics are tools employed to keep this threat at bay.

In a small subset of CLL patients, the disease can transform into a more aggressive form of lymphoma, known as Richter’s syndrome. It’s characterized by rapidly enlarging lymph nodes, fever, and weight loss. Though rare, this transformation necessitates a shift from CLL’s standard treatments to aggressive lymphoma therapies.

CLL sometimes tricks the body into attacking its cells. This autoimmunity can lead to anemia or a low platelet count, complicating the treatment landscape. Steroids or immunosuppressive drugs become essential to counteract this self-destructive trend.

Often overshadowed by more immediate concerns, CLL can significantly impact bone health. The disease, combined with certain treatments, can lead to bone thinning or osteoporosis. Regular bone density tests and supplements help manage this hidden complication. (7)

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