Fact 7. Role of Genetics: Is ALL Hereditary?
The specter of genetics looms large in many diseases, and ALL is no exception. While the majority of ALL cases aren’t directly inherited, family history can increase susceptibility. It’s a subtle but crucial distinction.
Twin studies offer a lens into the genetic dimension. Identical twins have an elevated risk of developing ALL if their sibling has the disease. However, this risk decreases significantly in non-identical twins.
Certain inherited syndromes, while not directly causing ALL, can elevate its risk. These include specific genetic disorders, though it’s important to note that they are rare.
It’s also intriguing to note that certain genetic mutations in the leukemia cells, while not inherited, can influence treatment responses. These mutations, acquired after birth, might dictate the disease’s progression and outcome. (7)
