Type 3: Acquired Angioedema
Acquired angioedema differentiates itself by its onset, usually manifesting later in life. While it mimics hereditary angioedema in its symptoms, its causes are distinct. It’s not rooted in genetics but emerges due to certain underlying medical conditions or medications.
Primary among its causes are autoimmune disorders. The body’s immune system, which typically defends against external threats, starts targeting its own tissues, leading to inflammation and swelling. Additionally, certain medications, particularly ACE inhibitors used for blood pressure control, have been linked to acquired angioedema.
Patients with acquired angioedema experience symptoms mirroring those of hereditary angioedema. This includes swelling of the deeper layers of the skin, potentially affecting the face, limbs, and even internal organs. Such episodes can be sporadic and unpredictable, further complicating diagnosis and management. (3)
