Becoming Acquainted with Transient Global Amnesia (TGA): Your 15 Key Facts Guide

2. Unraveling the Mystery: The Underlying Mechanisms of TGA

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Unraveling the Mystery The Underlying Mechanisms of TGA
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The brain is a marvel of intricate connections, and any disruption in this network can lead to fascinating phenomena, like TGA. While the precise cause remains unknown, experts have proposed several theories to explain why TGA occurs.

One such theory suggests a temporary disruption in the blood flow to specific areas of the brain responsible for memory, particularly the hippocampus. This interruption, although brief, can result in temporary memory loss.

Another theory revolves around the concept of cortical spreading depression (CSD), a wave of hyperactivity followed by a period of suppressed activity in brain cells. Commonly associated with migraines, some researchers believe CSD might play a role in TGA.

There is also a theory that links TGA to epilepsy, albeit a milder form. This theory proposes that a minor seizure in the memory-related areas of the brain could manifest as a TGA episode.

Stress has also been suggested as a potential underlying factor. Stressful or emotional situations could trigger the release of stress hormones that, in high levels, can affect the brain’s memory circuits. (2)

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