Cause 8: Insulin Resistance: The Unexpected Link in FTD
Insulin resistance, commonly associated with type 2 diabetes, has been drawing attention in neurodegenerative research. Surprisingly, it appears to be linked to an increased risk of developing FTD, revealing an unexpected connection between metabolic and neurodegenerative diseases.
Insulin resistance occurs when cells fail to respond properly to insulin’s signals, leading to a host of metabolic problems. But the effects aren’t limited to metabolic functions. Insulin also plays a critical role in the brain, influencing learning, memory, and neuronal survival.
In insulin resistance, the brain’s response to insulin may be impaired. This can disrupt neuronal communication, cause inflammation, and increase vulnerability to oxidative stress. Over time, these disturbances can contribute to neuronal death and the development of FTD.(8)
