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Getting to Know Korsakoff Syndrome: A Closer Look at 15 Key Facts

Diseases and ConditionsBrain Health

Fact 6. Genetic Predisposition: It’s Not Just About Alcohol

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Genetic Predisposition It's Not Just About Alcohol
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Alcohol misuse is a major risk factor for KS, but it’s not the only piece of the puzzle. Genetics also play a role in determining susceptibility to this condition. Certain genetic variations can make an individual more prone to developing KS.

Several genes are implicated in the development of KS. These genes influence the metabolism of thiamine, alcohol, and other related pathways. Variations in these genes can predispose individuals to thiamine deficiency and subsequently, to KS.

However, the genetic landscape of KS is complex. It’s not a simple matter of one gene, one disease. Multiple genes contribute to the risk, each adding a small piece to the puzzle. The interplay between these genes and environmental factors like alcohol use shapes the overall risk profile.(6)

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Our team of medical experts has created and reviewed this article to ensure that you receive the most accurate information available, in accordance with the latest research.

Sources:

1. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/wernicke-korsakoff-syndrome

2. https://my.clevelandclinic.org/health/diseases/22687-wernicke-korsakoff-syndrome

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724416/

4. https://rarediseases.org/rare-diseases/wernicke-korsakoff-syndrome/

5. https://www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/korsakoff-syndrome

6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545191/

7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693280/

8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392856/

9. https://www.ncbi.nlm.nih.gov/books/NBK539854/

10. https://www.ncbi.nlm.nih.gov/books/NBK430729/

11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370157/

12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492751/

13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546078/

14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805404/

15. https://www.caregiver.org/resource/wernicke-korsakoff-syndrome/