5. Transition to Secondary Progressive MS (SPMS): The Evolving Nature of RRMS
For many living with RRMS, there’s a looming question about the potential transition to Secondary Progressive MS (SPMS). This shift is more than a change in terminology; it marks a critical juncture in the disease’s trajectory.
Approximately 50% of those with RRMS may transition to SPMS within 10-20 years of diagnosis. This transition is characterized by a change in how symptoms manifest, moving from relapsing-remitting patterns to a gradual, steady progression.
What drives this transition is still a subject of intense research. Genetic factors, the accumulation of neurological damage, and even environmental influences are all under investigation. The mystery surrounding this transition speaks to the complex nature of MS as a whole.
But the transition is not necessarily inevitable or uniform. Some may never experience a shift to SPMS, while others might have a very slow progression. Ongoing monitoring and adaptation of treatment plans are crucial in this phase of the disease.
Educating patients about this potential transition is also vital. Knowledge empowers those with RRMS to actively participate in their care and decision-making. This transition, while significant, doesn’t mean an end to active and fulfilling life. (5)