11. Rapid Weight Loss: The Hidden Impact of Heart Disease
Unintentional weight loss can be a symptom of cardiac amyloidosis, particularly in the later stages of the disease. Weight loss is a common symptom in many chronic illnesses, but in the context of cardiac amyloidosis, it may be particularly concerning as it can indicate significant disease progression.
Weight loss in cardiac amyloidosis can be caused by a few different factors. Firstly, the accumulation of amyloid fibrils in the heart muscle can lead to heart failure, which can cause fluid buildup in the lungs and other parts of the body, including the abdomen. This fluid buildup, known as edema, can contribute to weight gain, but it can also mask weight loss. As the disease progresses, however, the heart may become less efficient at pumping blood, which can cause weight loss.
Secondly, the accumulation of amyloid fibrils can interfere with the digestive process, leading to malabsorption of nutrients and weight loss. This can happen if the amyloid fibrils accumulate in the gastrointestinal tract, preventing the absorption of nutrients from food.
Finally, weight loss can be a result of the body’s response to inflammation and other metabolic changes associated with cardiac amyloidosis. As the body tries to fight the disease, it can enter a catabolic state, where it breaks down muscle tissue to provide energy. This can lead to significant weight loss, especially in the later stages of the disease.
It’s important to note that unintentional weight loss can also be a symptom of other conditions, and not all patients with cardiac amyloidosis will experience it. However, if weight loss occurs alongside other symptoms of cardiac amyloidosis, such as shortness of breath, fatigue, and swelling in the legs and abdomen, it may be cause for concern and warrant further investigation.
Rapid weight loss can have serious consequences on a person’s overall health and should be addressed promptly. Consult a healthcare professional if you experience unexplained or significant weight loss, especially if accompanied by other cardiac amyloidosis symptoms. (11)
