Cause 9: Drug-Induced Liver Injury
Drug-Induced Liver Injury (DILI), a potential side effect of numerous medications, steps into the spotlight as a significant cause of liver damage. The liver, in its central role of metabolizing and detoxifying substances, is susceptible to injury from certain drugs. The damage can range from mild and reversible to severe and progressive, leading to cirrhosis in extreme cases.
The journey of DILI through the liver is unpredictable, with risk factors including the type of drug, dosage, duration of use, and individual susceptibility. Some medications are known for their hepatotoxic potential, necessitating careful monitoring and regular liver function tests during treatment.
Addressing DILI requires vigilance, awareness, and prompt action. Discontinuation of the offending medication is crucial, and in some cases, specific antidotes may be required. The emphasis is on prevention, through judicious use of medications, thorough patient education, and regular monitoring of liver function.
In the wider context of liver cirrhosis, DILI represents a preventable yet challenging adversary. It’s a condition that calls for attention to detail, patient-centered care, and a proactive approach to medication management. The journey towards safer medication use and preserved liver health is a collaborative one, requiring the concerted efforts of healthcare professionals and patients alike. (9)
