Symptom 2: Recurring Kidney Stones
Recurring kidney stones are a symptom primarily associated with MEN1. This can occur due to excessive levels of calcium in the blood, a condition known as hypercalcemia. The parathyroid glands, which regulate calcium in our body, can become overactive in MEN1, leading to excess production of parathyroid hormone and causing an imbalance in calcium levels.
Kidney stones are essentially hard deposits composed of minerals and salts that form inside the kidneys. The process is typically triggered when urine becomes concentrated, allowing minerals to crystalize and stick together. They can range in size and can be as small as a grain of sand or as large as a golf ball.
The recurring formation of these stones can cause severe pain during their passage through the urinary tract. Symptoms can also include blood in the urine, nausea, vomiting, and frequent urination. If you’re experiencing these symptoms regularly, it’s advisable to seek medical attention to address any potential underlying causes. (2)
