6. The Experience of Frequent Tripping: An Early Clue to HIBM

Frequent tripping or stumbling may be an early, yet overlooked, symptom of HIBM. While seemingly minor, it can serve as an initial clue to the presence of this disease, often predating more significant symptoms like muscle wasting.
This symptom is directly tied to the progressive weakness in the distal muscles, particularly those in the feet. As these muscles weaken, they can cause changes in gait and balance, leading to increased instability and a propensity to trip or stumble.
The occurrence of frequent tripping should not be disregarded as clumsiness. Instead, it should prompt further investigation, particularly when accompanied by other symptoms like muscle weakness. Early recognition of this symptom can lead to earlier intervention, potentially slowing the disease’s progression and improving overall quality of life. (6)