8. Dealing with Diabetes: Metabolic Complications of FRDA
In addition to the neurological implications, the eighth fact on our journey through Friedreich’s Ataxia centers on its metabolic ramifications, namely diabetes. Surprisingly, about 10% of people with FRDA develop carbohydrate metabolism issues, leading to diabetes or glucose intolerance, making it a crucial aspect of the disease.
The link between FRDA and diabetes hinges on the function of frataxin. This protein, whose production is significantly reduced in FRDA, plays a vital role in the pancreas’s islet cells – the body’s insulin producers. Without adequate frataxin, these cells struggle to function correctly, leading to reduced insulin production and consequent diabetes.
Aside from the genetic link, the physical limitations imposed by FRDA also contribute to diabetes risk. Reduced mobility can lead to weight gain and a sedentary lifestyle, both of which are known risk factors for diabetes. This ‘double whammy’ effect further heightens the chances of developing diabetes in FRDA patients.
Managing diabetes within the context of FRDA presents its unique challenges. It requires careful monitoring and control of blood sugar levels alongside the management of other FRDA symptoms. Moreover, some of the medications used to control diabetes may interact with the treatments for FRDA, requiring careful medical oversight. (8)
