Sudden fatigue is often associated with heart problems. It is overwhelming and not relieved by sleep and rest. If you feel a sudden need to stop after minimal physical activity, it’s a good idea to see a doctor. Fatigue is rarely the single symptom of MI, as it usually accompanies chest pain or shortness of breath.
Severe fatigue with no clear causes may be a sign of a heart condition.
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heart.org/en/health-topics/heart-attack
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European Heart Journal (2018) 39, 119–177. doi:10.1093/eurheartj/ehx393