9. Proteinuria and Medications: The Pharmacological Factor
We often turn to medication as a solution, but when it comes to proteinuria, the remedy can sometimes be the culprit. A range of medications can lead to or exacerbate proteinuria, making it crucial to consider drug interactions and side effects when undergoing treatment.
Let’s first talk about non-steroidal anti-inflammatory drugs (NSAIDs), the ubiquitous over-the-counter painkillers. Popping a pill for a headache might seem harmless, but frequent use of NSAIDs can place stress on the kidneys, allowing for the escape of protein into urine. While the majority of people may not experience this side effect, individuals with already compromised kidney function should tread cautiously.
Then, there are the more potent medications like certain antiretroviral drugs used to treat HIV. These can have a more substantial impact on renal health, contributing to a heightened risk of proteinuria. While the aim of such treatment is undeniably life-saving, it also calls for regular monitoring of kidney function to mitigate any adverse effects.
Chemotherapy also joins the list. Powerful agents used to kill cancer cells also have a known tendency to harm normal cells, including those in the kidneys. As a result, proteinuria can be an unintended side effect of cancer treatment. Patients often undergo a balancing act, where the need to eradicate cancer cells is weighed against preserving kidney function. (9)
