Fact 14. Prognosis of DLB: A Complex Picture
The prognosis of DLB is influenced by a multitude of factors, including the severity and progression of symptoms, the presence of comorbid conditions, and the individual’s overall health status. On average, the lifespan following diagnosis is approximately 6-12 years, although this can vary widely.
The course of DLB is typically characterized by a gradual progression of cognitive impairment, with worsening of visual hallucinations and motor symptoms over time. However, the disease course can be punctuated by periods of stability and even transient improvement, particularly with treatment.
Certain factors have been associated with a poorer prognosis. These include older age at onset, the presence of severe neuropsychiatric symptoms, rapid disease progression, and the co-existence of Alzheimer’s pathology. By contrast, a younger age at onset, milder symptoms, slower progression, and a good response to treatment can be associated with a better prognosis. (14)
