Fact 15. Treatment of DLB: A Multimodal Approach
The treatment of DLB involves a multimodal approach that addresses cognitive symptoms, psychiatric symptoms, motor symptoms, and sleep disturbances. Treatment typically involves a combination of pharmacological interventions, non-pharmacological interventions, and caregiver support.
Pharmacologically, cholinesterase inhibitors such as rivastigmine, donepezil, and galantamine are often used to manage cognitive symptoms and can also alleviate psychiatric symptoms. For motor symptoms, a cautious use of carbidopa-levodopa may be considered, although care must be taken due to the risk of exacerbating hallucinations.
For severe neuropsychiatric symptoms, atypical antipsychotics like quetiapine or clozapine can be used, but again, these must be used cautiously due to potential side effects. Sleep disturbances can often be managed with melatonin or clonazepam, depending on the specific sleep problem.
Non-pharmacological interventions are also crucial in the management of DLB. Physical therapy can help manage motor symptoms, while cognitive rehabilitation can help maintain cognitive function. (15)
