Cause 9. Kidney Disease: The Role of Erythropoietin
Kidney disease can lead to macrocytic anemia due to its impact on the hormone erythropoietin. The kidneys produce erythropoietin, which is responsible for stimulating the bone marrow to produce red blood cells. When kidney function is compromised, erythropoietin production may decrease, leading to a reduced production of red blood cells and the development of macrocytic anemia.
Chronic kidney disease (CKD) is a common cause of anemia in affected individuals. CKD can result from various underlying conditions, such as diabetes, high blood pressure, or autoimmune disorders. In addition to erythropoietin deficiency, individuals with CKD may also experience a decreased production of red blood cells due to factors such as iron deficiency, inflammation, or the accumulation of toxins in the body.
To address macrocytic anemia caused by kidney disease, it’s crucial to manage the underlying condition and support kidney function. This may involve implementing lifestyle changes, such as adopting a kidney-friendly diet, controlling blood pressure and blood sugar levels, and taking medications as prescribed by a healthcare provider. In some cases, erythropoietin-stimulating agents (ESAs) or iron supplements may be recommended to boost red blood cell production. (8)
