Symptom 9: Peripheral Neuropathy
Peripheral neuropathy often starts subtly in MLD patients. Initial signs can include a mild numbness or tingling sensation, especially in the hands or feet. Some may experience a sensitivity to touch, with even mild contact causing discomfort.
As MLD progresses, the symptoms of peripheral neuropathy can intensify and expand. Tingling may transform into a constant pins-and-needles sensation. The numbness might spread, affecting larger areas of the hands or feet. Some individuals also report feeling a sense of tightness or swelling in their affected limbs, even when no visible swelling is present.
Peripheral neuropathy in MLD is due to the buildup of sulfatides in the peripheral nerves. These nerves carry signals between the brain and spinal cord and the rest of the body. When these nerves are damaged, the transmission of these signals is disrupted, leading to the symptoms of peripheral neuropathy.
Recognizing peripheral neuropathy early can significantly affect management strategies. It’s important not to dismiss the early signs of numbness or tingling as temporary or inconsequential. Especially in the context of MLD, these symptoms might be indicative of advancing nerve damage that should be addressed.(9)
