Cause 10. Chronic Kidney Disease: A Hidden Contributor
Chronic kidney disease (CKD) can be an indirect yet significant factor in the development of pernicious anemia. As kidney function declines, the body’s ability to produce erythropoietin, a hormone responsible for stimulating red blood cell production, becomes compromised. As a result, individuals with CKD may experience a decrease in red blood cell count, leading to anemia.
In addition to impaired erythropoietin production, CKD can also negatively affect the body’s ability to absorb vitamin B12. This is because the kidneys play a crucial role in regulating the balance of nutrients in the body, including vitamin B12. When kidney function is compromised, the absorption of essential nutrients like vitamin B12 can become impaired, further increasing the risk of developing pernicious anemia.
The treatment of pernicious anemia related to CKD involves addressing the underlying kidney disease and providing supplemental vitamin B12 to ensure proper red blood cell production and function. This may include medications to manage CKD, dietary modifications, and vitamin B12 supplementation through injections, oral tablets, or nasal sprays.
Healthcare providers should closely monitor individuals with CKD for signs of pernicious anemia and regularly assess their vitamin B12 levels. By addressing both the kidney disease and the potential for vitamin B12 deficiency, healthcare professionals can help prevent the development of pernicious anemia and improve the overall health of individuals living with CKD. (10)
