Cause 2. Autoimmune Disorders: The Hidden Enemy
Autoimmune disorders can also contribute to the development of pernicious anemia. In these cases, the body’s immune system mistakenly attacks its own healthy cells, leading to a range of health complications. One such complication is the destruction of the cells responsible for producing intrinsic factor, a protein that is necessary for vitamin B12 absorption.
The most common autoimmune disorder associated with pernicious anemia is autoimmune atrophic gastritis. This condition occurs when the immune system attacks the stomach lining, leading to inflammation and atrophy of the stomach’s mucous membrane. As the stomach lining becomes damaged, it loses its ability to produce intrinsic factor.
Without intrinsic factor, the body cannot absorb vitamin B12 effectively, leading to a deficiency and the development of pernicious anemia. Treatment for this cause of pernicious anemia often involves addressing the underlying autoimmune disorder, as well as providing supplemental vitamin B12 to ensure the body has the necessary resources to produce healthy red blood cells.
It is important to note that other autoimmune disorders, such as lupus and rheumatoid arthritis, can also increase the risk of developing pernicious anemia. These conditions can cause inflammation throughout the body, which can interfere with the production and functioning of red blood cells. Healthcare professionals must consider the potential impact of these autoimmune disorders when diagnosing and treating pernicious anemia. (2)
