13. Enlarged Lymph Nodes: A Telltale Sign of Systemic Involvement
One of the more concerning symptoms is the enlargement of lymph nodes, commonly referred to as lymphadenopathy. These are usually non-tender, firm swellings that can be felt under the skin, especially in the neck, armpit, or groin areas.
Lymph nodes are vital components of the immune system. When they detect a threat, such as cancerous T-cells associated with mycosis fungoides, they can enlarge as they work to filter out these harmful cells and produce immune cells.
Not all lymph node enlargements are indicative of disease progression. Still, persistent swelling, especially if accompanied by other symptoms, should be evaluated promptly. It helps to determine if the cancer has spread or if there’s another underlying condition.
Treatment depends on the cause. If due to mycosis fungoides progression, systemic therapies might be initiated. Regular monitoring of these nodes is essential, and in some cases, a biopsy might be warranted to assess the nature of the enlargement. (13)
