5. Enlarged Lymph Nodes: The Body’s Filters React
Lymph nodes, part of our immune system, act as filters for harmful substances. They are located throughout the body but are most noticeable in the neck, underarms, and groin. In mycosis fungoides, these nodes can become swollen or enlarged – a condition called lymphadenopathy.
The primary cause for this symptom is the infiltration of the malignant T-cells into the lymph nodes. As these cells accumulate, the node enlarges. This is the body’s attempt to filter out the abnormal cells, leading to an increase in size.
Affected lymph nodes might be palpable – that is, they can be felt as small, round, movable lumps under the skin. While they are generally painless, some patients might experience discomfort or a heavy sensation in the affected area.
Enlarged lymph nodes can be indicative of the disease spreading beyond the skin. Thus, biopsies might be recommended to determine the extent of the disease and guide treatment. Additionally, it’s crucial to differentiate between lymphadenopathy due to mycosis fungoides and other potential causes, such as infections. (5)
