Spotlight on Squamous Cell Carcinoma of the Thyroid: The Top 10 Symptoms You Can’t Ignore

Introduction: The Unseen Threat – Primary Squamous Cell Carcinoma of the Thyroid

Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare and aggressive form of cancer that originates in the thyroid gland, positioned just below your Adam’s apple. Despite its relative rarity, it’s crucial to familiarize oneself with its manifestations. This knowledge could become vital if you or someone you know exhibits these symptoms.


Typically, PSCCT exhibits an array of symptoms, which can often be mistaken for less severe conditions. Thus, understanding these symptoms, their combinations, and knowing when to seek medical advice can make all the difference. Let’s delve into the specifics, dissecting the ten primary symptoms of PSCCT.

Symptom 1. Persistent Cough: The Subtle Sign of Trouble

Persistent Cough The Subtle Sign of Trouble


When it comes to a persistent cough, it can often be regarded as a mere nuisance, and many people fail to recognize it as a potential red flag for something far more serious. Indeed, the links between a constant cough and conditions such as thyroid cancer are not widely known, but they exist and are important to acknowledge.

Let’s start with the basics. A persistent cough is a cough that lasts for eight weeks or longer in adults or four weeks in children. While this may seem like a long time, it’s not uncommon for seasonal allergies or viral infections to cause a cough that hangs around for this length of time. Therefore, the duration of the cough alone isn’t enough to suggest a connection to thyroid cancer.

However, a persistent cough could also be a sign of something more serious, such as primary squamous cell carcinoma of the thyroid, if it is accompanied by other symptoms. Specifically, if the cough is non-productive (doesn’t produce mucus), it’s often dry and irritating, which is an atypical characteristic compared to common cold or allergy-related coughs.

The American Journal of Otolaryngology published a study that revealed a significant correlation between persistent non-productive cough and thyroid diseases. They found that the thyroid gland’s enlargement due to tumors often causes pressure on the trachea, leading to a cough.

PSCCT is an aggressive and invasive form of cancer that can extend beyond the thyroid, impinging on the trachea and larynx, causing persistent coughing. This symptom might be an initial sign that something isn’t quite right, and it’s important not to dismiss it. (1)

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