7. Endometrial Hyperplasia: A Hidden Consequence of Cowden Syndrome
Endometrial hyperplasia, an overgrowth of the lining of the uterus, is a common symptom in women with Cowden Syndrome. It presents as an unusual thickening of the endometrium, the tissue lining the uterus. While this condition isn’t cancerous, it can increase the risk of developing endometrial cancer if left untreated.
The hormonal imbalance, particularly an excess of estrogen relative to progesterone, is usually behind endometrial hyperplasia. For women with Cowden Syndrome, genetic factors play a crucial role in the development of this condition. Symptoms of endometrial hyperplasia can include heavy or prolonged menstrual periods, bleeding between periods, and, in postmenopausal women, any bleeding.
Given the increased risk of endometrial cancer in women with Cowden Syndrome, regular gynecological examinations, including transvaginal ultrasounds and endometrial biopsy when needed, are recommended. These procedures can help detect endometrial hyperplasia and any potential malignant transformation early.
Remember, it’s essential for women with Cowden Syndrome to inform their healthcare provider of any changes in their menstrual cycles or any unusual bleeding. If endometrial hyperplasia is diagnosed, treatment will focus on correcting the hormonal imbalance, often through hormonal therapy, and monitoring for any signs of cancer. (7)
