Stage 3: Advanced Spread
When cholangiocarcinoma advances to the third stage, bloating becomes a pronounced symptom. This isn’t the kind of bloating one feels after a heavy meal; it’s persistent and often accompanied by swelling in the abdominal region. It results from the tumor growing in size and pressuring adjacent organs, which, coupled with fluid buildup, gives the abdomen a distended appearance. Frequent and unexplained bloating, especially if coupled with other symptoms, should serve as a warning flag.
At this stage, bouts of fever become more frequent. These aren’t just minor temperature spikes, but often pronounced fevers, indicating the body’s fight against the cancerous invasion. It’s a natural immune response but signifies that the condition is worsening. Persistent or recurrent fever, especially without a clear external cause like an infection, demands immediate medical attention.
Another unsettling symptom indicative of Stage 3 is persistent nausea, sometimes accompanied by bouts of vomiting. With the bile duct severely compromised by now, the body struggles with digestion. This internal chaos manifests externally in the form of these distressing symptoms. Prolonged nausea or unexplained vomiting episodes, especially if devoid of other apparent causes like food poisoning, should be investigated further.
With the disease progressing and the body in turmoil, there’s a noticeable dip in appetite. Eating, which once was a pleasure, now becomes a chore. This isn’t just an occasional lack of hunger; it’s a consistent, concerning aversion to food. It results from the combined effects of internal discomfort, nausea, and the body’s general state of disarray.
The compromised bile flow not only affects the stool but also deprives the skin of its healthy color. While jaundice gives a yellowish hue, there’s also an overarching pallor—a grayish or ashen tint—that becomes noticeable. It’s as if the vitality is being sapped from the person. This change in complexion is another symptom of the body’s continuing struggle against the advancing cholangiocarcinoma. (3)
