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The Cleft Lip Story: 15 Details that Matter

Diseases and Conditions

2. Rooted in Genetics: The Role of DNA in Cleft Lip

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Rooted in Genetics The Role of DNA in Cleft Lip
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When it comes to understanding the origins of a cleft lip, genes often come into the spotlight. Like many other conditions, a cleft lip can be passed down through generations, laying testament to the power of our DNA. Though it’s not solely a genetic condition, inheriting certain gene combinations can increase the likelihood of a child being born with a cleft lip.

Researchers have identified several genes that, when mutated or combined in a specific way, can lead to the development of a cleft lip. However, it’s not a straightforward ‘inherit and manifest’ situation. Environmental factors during pregnancy, like exposure to certain drugs or infections, can influence its manifestation even when the genes are present.(2)

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Our team of medical experts has created and reviewed this article to ensure that you receive the most accurate information available, in accordance with the latest research.

Sources:

1. https://www.ncbi.nlm.nih.gov/books/NBK482262/

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925974/

3. https://www.mayoclinic.org/diseases-conditions/cleft-palate/symptoms-causes/syc-20370985

4. https://www.nature.com/articles/s41599-020-00677-7

5. https://journals.lww.com/plasreconsurg/Citation/1992/01000/Harelip_Surgery_in_Ancient_China__Further.33.aspx

6. https://pubmed.ncbi.nlm.nih.gov/31810279/

7. https://pubmed.ncbi.nlm.nih.gov/18022477/

8. https://stanfordhealthcare.org/medical-conditions/mouth-and-jaw/cleft-lip-cleft-palate/treatments/complications.html

9. https://pubmed.ncbi.nlm.nih.gov/34293942/

10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922396/

11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825064/

12. https://pubmed.ncbi.nlm.nih.gov/24754915/

13. https://pubmed.ncbi.nlm.nih.gov/19642758/

14. https://pubmed.ncbi.nlm.nih.gov/34033944/

15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671751/