4. FL’s Invisible Markers: Genetic Mutations Hold the Key
Peek under the microscope, and the world of follicular lymphoma is a realm of codes, patterns, and perplexing sequences. Genetics, in particular, throws light on some of the deepest mysteries of FL. Mutations are those silent markers, microscopic changes in DNA sequences, which can be instrumental in triggering FL.
BCL2 and BCL6 gene alterations are typically seen in most FL cases. These mutations contribute to the abnormal survival and proliferation of lymphocytes. But the intrigue doesn’t stop there. In certain cases, these mutations alone don’t cause FL; they partner with other genetic alterations to set the stage.
The intricacy of these genetic interplays brings to the fore an interesting aspect: that FL’s genesis is not just about one faulty switch. Instead, it’s about a cascade of genetic events, a series of molecular dominoes that topple in quick succession. And these aren’t mere random changes; they follow a pattern, a sort of biological script. (4)
