Cause 10: Hemolytic Anemia Due to Metabolic Disorders
When the Body’s Chemistry Goes Awry
Metabolic disorders, such as pyruvate kinase deficiency and disorders of the urea cycle, can cause hemolytic anemia by impairing the normal function and survival of red blood cells. In the case of pyruvate kinase deficiency, a genetic disorder, the affected individuals lack sufficient levels of an essential enzyme required for red blood cell metabolism. This deficiency leads to the premature destruction of red blood cells and the development of hemolytic anemia.
Treatment for hemolytic anemia due to metabolic disorders depends on the specific condition and may include enzyme replacement therapy, dietary modifications, or supportive care such as blood transfusions and iron supplementation. In some cases, bone marrow transplantation may be considered for patients who do not respond to other treatments.
Early diagnosis and appropriate management of metabolic disorders leading to hemolytic anemia are essential for preventing complications and improving the patient’s quality of life.
