Cause 5: Microangiopathic Hemolytic Anemia (MAHA)
A Consequence of Damaged Blood Vessels
Microangiopathic hemolytic anemia (MAHA) is a type of hemolytic anemia caused by damage to small blood vessels in the body. This damage can lead to the formation of blood clots, which can shear red blood cells as they pass through the affected vessels, resulting in their destruction and the subsequent development of anemia.
Several conditions can cause MAHA, including thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), disseminated intravascular coagulation (DIC), and malignant hypertension. These conditions can be life-threatening, and early diagnosis and treatment are crucial for improving patient outcomes.
Treatment for MAHA depends on the underlying cause and may include plasma exchange, immunosuppressive therapy, anticoagulants, and blood pressure management. In some cases, kidney dialysis or a kidney transplant may be necessary, particularly in cases of severe HUS.
Recognizing the signs and symptoms of MAHA and seeking prompt medical attention can be lifesaving for those affected by this complex and potentially dangerous form. (5)
